ARN14988 is a potent inhibitor of acid ceramidase (IC50 = 12.8 nM for the human enzyme).1 It inhibits acid ceramidase activity and increases levels of C16 dihydro ceramide (Item No. 24369) and C16 ceramide (Item No. 10681) in A375, G361, M14, MeWo, MNT-1, and SK-MEL-28 melanoma cells. ARN14988 also reduces growth of A375 and G361 melanoma cells (EC50s = 41.8 and 67.7 µM, respectively).
WARNING This product is not for human or veterinary use.