Hesperetin-13C-d3 is intended for use as an internal standard for the quantification of hesperetin (Item No. 10006084) by GC- or LC-MS. Hesperetin is a citrus flavonoid that has been reported to lower plasma cholesterol.1 Hesperetin reduces the transcription of ACAT2 mRNA in HepG2 cells and reduces ApoB protein synthesis in a dose-dependent manner. The EC50 for these responses is approximately 50 µM. Hesperetin also inhibits histamine release from IgE-challenged RBL-2H3 cells, with a potency comparable to the antihistamine azelastine (Item No. 20873).2WARNING This product is not for human or veterinary use.